The Zebrafish Xenograft Models for Investigating Cancer and Cancer Therapeutics

Mouse xenograft models vs GEM models for human cancer therapeutics.

Zebrafish cancer models

Several models of cancer have been generated in zebrafish. Owing to space constraints, we will focus exclusively on heritable tumor models in the zebrafish. These are summarized in Tables 1 and 2. Table 1 lists all models according to cancer type and organ affected. The vast majority are transgenic lines expressing oncogenes driven by tissue-specific or ubiquitous promoters. Table 2 summarizes ...

Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy.

Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored human leukemic cell xenograft in zebrafish embryos. Human leukemic cell lines and blast cells sorted from patients with acute myelogenous leukemia were injected 48 hours post-fertilization and rema...

Fish tales: The use of zebrafish xenograft human cancer cell models.

Advances in scientific techniques have provided researchers with exceptional new opportunities to identify and monitor changes between different cancer types, during different stages of progression, between individual tumor cells and in the surrounding stroma. The wealth of information that can be obtained from new scientific techniques places additional requirements on the conventional cancer ...

Cox and Frailty Models for Analysis of Esophageal Cancer Data‎

‎By existing censor and skewness in survival data‎, ‎some models such as weibull are used to analyzing survival data‎. ‎In addition, parametric and semiparametric models can be obtained from baseline hazard function of Cox model to fit to survival data‎. ‎However these models are popular because of their simple usage but do not consider unknown risk factors‎, ‎that's why cannot introduce the be...